The Japan Society for Menopause and Women’s Health
Journal of the Japan Society for Menopause and Women’s Health
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V0l.20-1
1 Department of Obstetrics and Gynecology, Taniguchi Hospital
2Department of Health Science, Kobe City College of Nursing
1Fumiaki Suzuki, 1Akiko Shouno, 1Masahiro Tahara, 1Toshihiko Tomiyama, 1Masaaki Ono,
1Takeshi Taniguchi, 2Takahiro Kasamatsu
Summary
Objectives: To examine the effects of daidzein-rich isoflavone aglycone (DRI) supplementation on menopausal symptoms and oxidative stress in middle-aged women.
Methods: Subjects were 29 middle-aged women (18 undergoing menopausal disorder treatment and 11 undergoing anti-aging treatment) who visited a hospital in Osaka Prefecture for health assistance. Subjects took 40 mg of a DRI supplement after breakfast daily for 8 weeks. Blood tests for reactive oxygen metabolites (d-ROM), an indicator of oxidative stress, and biological antioxidant potential (BAP), an indicator of antioxidant defense status; the simplified menopausal index (SMI) test were conducted before and after DRI supplementation.
Results: In all subjects, DRI supplementation had no effect on blood parameters. In subjects with untreated menopausal disorders, the mean SMI score decreased significantly (p<0.05) from 63.8 ± 6.7 before supplementation to 42.9 ± 3.8 after supplementation. In all subjects, mean d-ROM levels decreased significantly (p<0.01), whereas mean BAP levels increased significantly (p<0.01). The degree of antioxidant potential, calculated using the modified BAP/d-ROM ratio (BAP/d-ROM/7.54) increased significantly (p<0.01).
Conclusions: Supplementation with DRI with a high antioxidant potential may reduce menopausal symptoms and help prevent oxidative stress. Furthermore, DRI supplementation may effectively make middle-age women more comfortable and improve their quality of life.